Archived record · Edyssy 2014
An Ltq-Orbitrap Elite With Etd For The Keck Proteomics Facility
- Agency
- NIHNational Institutes of Health
- Principal investigator
- Yinsheng Wang
- Institution
- University of California Riverside
- Amount listed
- $600,000
- Period
- June 1, 2013 to May 31, 2014
Abstract
DESCRIPTION (provided by applicant): Funds are requested for the purchase of a Thermo LTQ-Orbitrap Elite mass spectrometer with electron transfer dissociation (ETD) capability. The requested instrument will be installed at, and managed by the W. M. Keck Proteomics Facility at the University of California Riverside. There are a core group of 14 NIH-funded investigators at UC Riverside who require extensive access to the proposed LTQ-Orbitrap Elite system for proteomic analysis. The progress of these research projects is currently hampered by the lack of a high- performance LC-MS/MS system for global proteome quantification, large-scale mapping of post-translational modifications, protein complex, and protein conformation studies. The availability of the proposed instrument will have an immediate and positive impact on the progress of these research projects. In particular, the high scan rate of the linear ion trap, together with the high mass-resolving power and high mass accuracy of the Orbitrap mass analyzer, provides capability in identifying and quantifying a large number of proteins with high confidence. In addition, the availability of electron transfer dissociation as an ion dissociation technique on the proposed instrument facilitates the unambiguous identifications of post-translational modifications with great accuracy. The availability of this state-of-the-art proteomis platform will further promote biomedical research at UC Riverside and enhance the research experience of students and post-docs from under-represented minority groups. Public Health Relevance Statement: PUBLIC HEALTH RELEVANCE: The proposed LTQ-Orbitrap Elite mass spectrometer will benefit the research programs of a large group of NIH-funded investigators whose research requires the access of a high-performance mass spectrometer for proteomics research. The outcome of these research projects will improve our understanding of many human diseases including cancer, diabetes, and virus infection. Biomedical Research;California;Dissociation;Electron Transport;experience;Funding;Funding Applicant;instrument;Ions;Maps;mass analyzer;mass spectrometer;Minority Groups;Performance;Post-Translational Protein Processing;Postdoctoral Fellow;protein complex;Protein Conformation;Proteins;Proteome;Proteomics;Research;Research Personnel;Research Project Grants;Scanning;Students;System;Techniques;Underrepresented Minority;United States National Institutes of Health;Universities
Reading this record as an applicant
The record names Yinsheng Wang at University of California Riverside as principal investigator. When a professor holds an award like this, part of the budget usually goes to people: graduate research assistants, a postdoc or a technician. Shorter awards are often one year of a renewing project, so check whether it was continued. Look up the investigator’s current awards before you write; a 2014 record is a lead, not a promise. Before you do, read up on getting a letter from a well-known investigator.
Start with the investigator’s faculty page and recent papers, then search their name in NIH RePORTER or NSF Award Search to see what is active now. The grant search guide walks through it.